Leadwerks works on here on Manjaro (Quick install Arch distro) with XFCE, Gnome 3, KDE and MATE for me. Those are the environments I have used with Leadwerks. Leadwerks has worked on Mint/Cinamon for me before. It's worked on Ubuntu Unity of course for me. Infact KDE/Fedora 21 too....
Fact is, it does work very well on other distros and DE's too. So... yeah.